I don't have a Striker but I did just pick up a Magnum Research Lone Eagle in 22-250. I've never shot a rifle caliber pistol other than a friends 22 Hornet before. I shot 16 shots (ten of them over 1.5 hours of barrel break in and scope sighting) before I put on the muzzle brake...ouch!
I moved from the 25 to the 50 and then to the 100 yard range. On the last 15 shots (of a total of 55) I quit fiddling with the scope and shot three groups, 1.7, 2.5 (damn fliers!) and 1.8". Not bad for a rookie on the first time out using the cheapest factory ammo I could find (Rem).
I think that the barrel and twist are the same for the Striker and I would assume you would get similar or better results, depending on your skill level.
With a good load and some trigger work I think that this pistol will easily shoot sub MOA off the bench, I think it's likely the Striker would do the same. I have a Weaver 2.5x8 on mine.
It's a fun pistol...did I mention the huge fireball?
Any one have any recommended loads?
Steve-O