I have never hunted a buffalo, but if I could hunt a buffalo I used a 458 Lott rifle caliber

.375 H&H with .450 Dakota along if needed for follow up.

Model 70 Pre'64. .375 H&H Magnum

458 win mag, with 500 grain X bullets and solids.

Not very exotic or sexy but DEADLY every time.

When they make something more effective, I'll buy it!!

2 Buff 375h/h 300swift A-frame.

2 Buff 416 Rem 400 triple shoks

The 375 was a 700AWR rem. and the 416 was a Win. 70 custom african express. When and if I return(to africa) a dakota 76 in 404 jeffery will accompany me. Hopefully, upon awakening, this Obama mess will turn out to be a reallllly bad dream and I can return to africa after all.

4 x 458wm. Three with 500gr Woodleigh solids. One with 450gr North Fork solids.

I've only shot one Cape Buffalo. It was with my .375 RUM and a 300 gr Barnes TSX. I've taken this rifle over twice and used it on 17 PG animals from Steenbuck to Eland. I don't forsee me ever needing anything bigger.

3 Buff with Win 70 Safari Express .416Rem w/400gr Swift and 370gr GSC solids

Two buffalo, both with the same combination: a .500NE double with Woodleigh softs at about 50 yards...effective with good penetration.

The only one I've killed was with a .458 Lott using a 500-grain Speer African Grand Slam round nose soft point bullet at a muzzle velocity of 2,250 fps. The distance to the animal was approximately 30 yards. The shot was broadside as he was walking. The herd was undisturbed and had just gotten up from their mid-day siesta. I hit him in the middle of the shoulder and he dropped at the shot. Based on the moan, it took him about 5 seconds to expire. The bullet did not exit.

Three Buffalo with my 470 Mbogo and Swift 500 grain A-Frames.
Take care
Dave

Just wanted to give Rob some more work to do in tallying this one:

1 cape buffalo:
.416 Rigby
380-grain GSC FN at just over 2500 fps MV
50 yards range, almost broadside, "quartering" toward me a bit, as he grazed in a mopane thicket, unaware.
The 42-inch Botswana bull bucked upward like a rodeo bull, whirled 90 degrees and ran away, disappearing in the Mopane before I could shoot again, ran only 50 yards before falling and bellowing death.
All that despite a smashed onside humerus and a hole through his heart and both lungs, and out the other side..
Insurance was paid on the ground with another GSC FN between the shoulders, into the spine and out the brisket.

I will have more, hopefully with a spear next time.

And just to clutter the thread with other big bovines, since I would only hunt them with cape buffalo capable rifles:

1 water buffalo:
460 Wby first shot double lung 500-grain Factory soft, required finisher with my .375 H&H and Remington factory load of 300-grain Swift A-Frame, neck shot.

2nd water buffalo:
2 shots with a .416 Rigby and 350-grain Barnes X-Bullets at 2700 fps. Another double lung followed by a neck shot.

1 bison:
1 shot with 404 Jeffery and 380-grain North Fork soft point.

2nd bison:
.510/460Wby Imp. JAB
First shot with 570-grain Barnes XLC at just over 2400 fps, double lung.
Second shot with 570-grain GSC FN, which dropped him as he ran off.
That Texas heart shot exited, full length.