I'm not going to afrika or alaska.
.22lr....small game
12 ga pump...birds and such
6.5x55....deer and .....stuff
.35 whelen....for everything else

.22 LR

.30-06

.243 Win
.30-06 Sprg

If I ever go to Africa (ha!)
.375 Ruger

Simple:

.223 and.270 for state side use.
.375 for anything else. Or any place I decide to turn it loose on.....

BT

Well ya didn't really go into just what you are going after..(in North America)
If you are including Sod Poodles, Chucks, and Diggers along with big game, then;
25-06
.338 Win Mag

If you just after deer sized game and up, then;
.270 Win
.338 Win Mag

Africa is a whole 'nother ball game..

That's a lot of ground to cover
but for me it would be:
223 Remington
7x57mm Mauser
and Africa 338 Win Mag

.260 or 7mm-08 for all deer size game. 338 win. for all the. rest

Easy answer for me. My .270 WSM and .358 STA. The WSM can do it all from groundhogs to Elk. The STA outperforms the .375 H&H. Good shooting.

good to be different i quess
300 savage
308 norma mag

416 rigby for africa will never afford the hunt so i don't presently own a 416

470 capstick
300 H+H
22 hornet

I have most of them, but if forced to cull, my go-to calibers are:

270 Win
300 Win Mag.
416 Rigby for Africa

6mm/.284 -varmints, coyotes & them little central TX whitetails
7mm Rem. Mag. deer up
.416 Rigby big mean bears & maybe Africa

Man this is tough… not that I have any where as many Rifles as most… but to just pick to….

It’s un-American

But here goes:
338WM
450 Marlin

Good thing I don’t need to make that choice.

This is just rifles I can only have 2 of and I can keep my other non-rifles/hand rifles from .22LR up to .45-70 right?

Do I get to keep my varminter's separate too?

If all the above hold true I'd keep the .300 H&H and the .458 Lott.

If the above doesn't hold true, .220 Swift or .22-250 and .375 H&H.

Africa is .458 Lott if I only get to take/keep one but I'd be ok with .375 H&H if need be.

.243

.338 win

cheers
Allan

7 MM Mag I prefer Rem mag. myself . 33/378 Stops most anything on this planet. , .284 for small to large plains game 100-180 projectiles . 33/378 for the rest of them critters .

Shoot Straight Know Your Target . ...