If the grip cap has the little plastic Ruger medallion in it, you have to pry it out to expose the screw. You should order a new insert first, as the old one will not be reusable.
Brent, From what my local gunsmith told me, the brass medallions aren't available from Ruger. I had my Ruger .416 bead blasted and blued and the grip cap is the only thing that is still shiney. I didn't want to replace it with the red one.
I might buy a Dakota grip cap from Brownell's and have my initials engraved on it and replace the Ruger cap.
Not a big deal right now but it just started moving a little, side to side and I wanted to tighten it before it got outa hand sometime when I was hunting or something.
I'll call Ruger, they'll probably want it sent to them.