I recently bought a S&W combat magnum and the previous owner had the sights set for 6 o'clock hold. I have always aimed center mass and really dont want to have to change point of aim for one weapon. Can the pistol be bore sighted using a laser boresighter? I just want to get as close as possible without chasing the zero all over the place. Does anyone have any advice on sighting in a revolver.

You don't need to do that at all. Get a pistol rest (MTM for example) or just a plain rest for the barrel, or if not, just the grip. Take 6 rounds of ammo. Fire 3 rounds using the hold you want. Be aware that a 6 o clock hold is very precise (more precise than a 3-9 o'clock hold). But if you want a center hold then center of what? Try something like this as a target (you can probably find it on the internet)

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Hold the top of the front sight (and the top of the rear sight "leaves" on the line. Adjust sights!
Should not take more than 6 rounds. The combat magnum has fully adjustable sights. What range will you be sighting it? At 25 yards, the difference in the 6 o'clock and 3-9 o'clock holds should be about 3 inches
Peter.

bore sighting a handgun doesn't work to well because the gun is in recoil already. this is one of the reasons why heavier bullets strike a different impact point that lighter ones. like peter says, 6 rounds should do your sighting for you

It makes perfect sense now. Thank you both for the advice that is why I always ask here first. Thanks again

Move the rear sight up 3 clicks you'll be real close.

Now why didn't I think of that?!!!
Peter.