I would like to hunt white tail deer with a 100 to 115 gn bullet what's your favorite bullet powder combination for deer the avg shot where I hunt is 200 to 300 yds thanks for your help

Mine likes 49gr of IMR-4350 with 120gr Nosler Partitions. Seat them out long.

In my 25-06 I use IMR 4831 for all bullets from 75 to 100 grains and IMR 7828 for anything heavier.

I use standard rifle primers with the IMR 4831 and magnum primers with the IMR 7828.

my Vanguard 25/06 also likes IMR4831. My whitetail load is 53.5gr IMR4831, 100gr Partition,CCI200LRP,
Rem brass, COL 3.168. I use this same load in a Savage 110fp except the bullet is a 100gr Sierra MK HPBT. This is my long range prairie dog rifle that shoots minute of PD at 400+yds.
This load is well under max.
GOOD LUCK and GOOD SHOOTING!!!

I'm loading 100gr TSX's or 100gr Sierra Pro Hunters with near max load of RL22. Both of these work well in thickets or open areas but I prefer the TSX's in the thickets so I have a blood trail.