Has anyone played with this round useing 80gr bullets? What velocity what barrel length & what twist?

I believe in the next 2-3 months you should get plenty of answers. I have talked to Dave Kiff of PTG and Dave Manson of Manson Reamers, they are both experiencing lots of orders for 22-6mm A.I. reamers. Looks like the American Rifleman article will help the reamer makers eat better. I have order'd a reamer in this cal, a #7 straight taper 8" twist barrel, and the Redding S dies.

Well can't say anything about the 22-6mmAI never had one. My smith years ago had both a 22-244AI and a 224 Clark. And there was a slightly different version the 224TTH that was the new super 22 a couple of years ago. I would look to articles for the 224TTH for some info with 80gr bullets.

I loaded for and shot the 22-244AI and 224 Clark. At the time (20 yrs ago) long 22 cal bullets were few and far between. Plus the twist he had wouldn't handle them anyway. Great varmint rd but I also has some types of bullets not reach the target. After shooting them I opted to simply build a 22-250.