I have a 22-250 with a 1 in 12 twist ( used a pull of barrel for a free gun project)
What bullet wieghts should I try first?
Haw about powders? I've read IMR 4064 and 3031 work well What do you think?

The 52-55 grain bullets are the classics for the .22-250. Mine with 1:12" twist will shoot 60 grain flat base PSP bullets well. That's about the max.

4895, either the H or IMR sorts, is hard to beat. 4064's a great choice, too. I've seen it claimed in print that 4064 was originally made for .220 Swift factory loads, but I wasn't there at the time.

Ditto on the 50-55 grain bullets.....I like many of the 52/3 fbhp for accuracy in the 22-250's I have had.....and similar reccomendations on the Powders......IMR 4895 and 4064 do well..Win 748 meters good and in a few loads did good in a couple of guns in 22-250....standard or BR primers worked with all the powders.....HTH..good luck and good shooting-loading!!!

cant shoot 69grs in a 1-12 twist. tried 5 in my 223 and only one hit the paper at 100.

An exception is the old Speer 70 grain semi-spitzer. It's no longer than a 60 grain spitzer. (It's length that counts, mainly, for stabilization at a given twist.) Wonder if they still make those?

40-60g bullets, with 50-52 probably being the most accurate out of a 1-12. The guy above is right, 69's don't work in the 1-12's tried it once too, threw them though the target sideways at 50 yards. I use 41g's of H380 behind a 50g bullet of choice, when I run out of H380 I'm going to switch to Varget or something similar.

I think your best bullets may well be the Sierra 52gr. HPBT and the Nosler 55gr. Bal.Tip. You might get away
with using the 60gr bullets, nothing heavier will stabilize properly. IMR4064 is a great powder in this caliber
although it's a pain in the old wazoo to meter. 34.1grs. is about the most accurate load with the bullets
mentioned. It'll exit a 24" tube at about 3500fps. which is fast enough if you want your barrel to last for a
while. Best wishes.

Cal - Montreal

Thanks for all the info this is my first "smaller" caliber rifle