I load the Hornady 52g HPBT Match bullet with 36g of Varget and a Winchester primer and Rem brass. I have never used H322. I have found IMR 4064 very good in the 22-250, but I was not getting as much velosity with the accurate loads.
I think you will find H-322 a bit to fast for the 22-250 round. IMR-4064, REL-15, Varget are better suited to that cartridge. Also the twist rate will determine what weight bullet is best to use. If your 22-250 has a 1 in 14" twist it will like light bullets. If it has a 1 in 12" twist it will like the heavy bullets best. The 22-250 is a fine shooting round and peak accuracy bore life is around 2500 rounds.
May I ask why H322?? I shoot a 22-250 so much,I buy the cheapest bulk 55 gr bullets I can find; and run 35 grains of 4064 through it. I have killed everything from foxes to Mule Deer with this load.
I use mostly IMR-4064 in my .22-250, but have also had good luck with Win. 760. Lots of shooters seem to like Varget or H-380, but my rifle does not care for either.