I'm now using a loading in my Ruger Vaquero of 20g H L'IL Gun behind a 260g Nosler Partition HP, ignited by CCI Large Magnum Primers. The combination gives excellant accuracy with surprising velocities. One word of caution...this loading is only safe in Ruger revolvers or firearms that are designed for these higher modern pressures. I got the loading information from Hodgdon Pistol Data
Here's the first critter I took with the combination.