I have used 250 grain cast lead bullets meant for the 45 Colt sized .454 over something like 30 grains of 2400. They ran about 1,100 FPS if I recall correctly and at 50 yards with open sights I was shooting 1.5" groups so the slightly undersized bullets didn't seem particularly wobbly in the bore.
Makes for very cheap plinking and recoil is several steps below mild.
Many are having a lot of success with Trail Boss powder. Not a lot of energy, but filling the case almost to capacity and avoiding hangfires...the rounds are a lot of fun to shoot.