I do it all the time. They can be very destructive on small kangaroos and pigs.
Although, quite often I have seen more damage (external) done with the 270 and 300 grain Hornady round noses.
A load I like a real lot in the 375 is 220 Hornadies and 39 grains of one of our Australian powders that I think Hodgdon sell as H4227 Extreme.
Seated to the cannedlue ansd with Fed 210s, the accuracy is simply amazing. Does a bit over 2000 f/s, so is sort of like a super accurate 375 Winchester.
Mike
375s with good barrels are like most calibers that havea small case capcity for the bore size, that is, shoot different weights to different elevations.
Often if you laod the ligh bullet back they will come togtherm, but that would defeat your purpose for Africa.
I think there two solutions, one 100% success and one a maybe.
The "maybe" is to try different powders such as ball powder and stick powder.
Our Ausralian powders that Hodgdon sells as Extreme often shoot to different points to IMR and Reloader powder.
The 100%er is to get premier reticules to put a reticle with verticle dots in it.
That works great for things like the 22/6mm Imp with a zero out 700 yards with the dots and the "cross wire" xeroes for normal ranges.
Mike