No, I doubt you would ever see a difference on a bear. If you did see a difference, given that the bullets had a sim. jacket construction and core hardness, you would probably see that the 300 did more dammage than the 350. That my friend, is splitting hairs though.

I am thinking about moving up to 350gr. bullets in my .375 H&H for additional wallop at up close, Bear backup. The K.O. factor is increased from 40 to 45 on the scale. Keep in mind this load would be used for a 20 yard or less hammer.
Would I gain that much extra ?
Does anybody have any load data for this?
Thanks to all of you for in put. I have talked to a few about this before but I believe " Never enough research"
Thanks Maddog