Would you use a single shot rifle on grizzly, buffalo, or any other for of a big mean stompin' thing that could quickly change your additude about doing so? By the way this would be using the same calibers as you would use ina bolt gun, double, or whatever type of repeater you hunt with.

not in this lifetime..i kinda like it here and would like to stay around as long as possible

If the range was long, and you were good, I suppose...otherwise OUCH!

For me, I'd use the action I'm most comfy wiht anyway, a bolt gun

I shot a falling block for a long time and you can reload them pretty fast if you practice, not quite as fast as a bolt and not nearly as sure (you can drop the cartridge) but pretty fast.carry your ammo on your wrist or the butt of the rifle.
To answer the question,the answer is Yes.
I asked a guide once if he could shoot from his horse? His repy was
"I can get one good shot"

I have used a Ruger #1 in 416 Rigby to take Grizzly bear. 4 shots in under 30 seconds. The bear was dead with the first round but didn't know it.

http://perfectunion.com/forums/showthread.php?s=&threadid=1243

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AlleninAlaska