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The Pangolin / COVID-19 Connection
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It was first suggested that COVID-19 might have originated with Pangolins. I believe initially this was a joke to scare the Chinese from decimating the Pangolin population. However, it seems there is a definitive link between coronavirus found in bats and pangolins and COVID-19. Good news for Pangolins. Let's hope the Chinese who survived will think twice before purchasing any more Pangolin scales.

Now if we can just create an illness linked to the use of Rhino horn...

COVID-19 - Mother Nature's anti-poaching unit in action.

quote:

Genomic Study Points to Natural Origin of COVID-19

Posted on March 26th, 2020 by Dr. Francis Collins

No matter where you go online these days, there’s bound to be discussion of coronavirus disease 2019 (COVID-19). Some folks are even making outrageous claims that the new coronavirus causing the pandemic was engineered in a lab and deliberately released to make people sick. A new study debunks such claims by providing scientific evidence that this novel coronavirus arose naturally.

The reassuring findings are the result of genomic analyses conducted by an international research team, partly supported by NIH. In their study in the journal Nature Medicine, Kristian Andersen, Scripps Research Institute, La Jolla, CA; Robert Garry, Tulane University School of Medicine, New Orleans; and their colleagues used sophisticated bioinformatic tools to compare publicly available genomic data from several coronaviruses, including the new one that causes COVID-19.

The researchers began by homing in on the parts of the coronavirus genomes that encode the spike proteins that give this family of viruses their distinctive crown-like appearance. (By the way, “corona” is Latin for “crown.”) All coronaviruses rely on spike proteins to infect other cells. But, over time, each coronavirus has fashioned these proteins a little differently, and the evolutionary clues about these modifications are spelled out in their genomes.

The genomic data of the new coronavirus responsible for COVID-19 show that its spike protein contains some unique adaptations. One of these adaptations provides special ability of this coronavirus to bind to a specific protein on human cells called angiotensin converting enzyme (ACE2). A related coronavirus that causes severe acute respiratory syndrome (SARS) in humans also seeks out ACE2.

Existing computer models predicted that the new coronavirus would not bind to ACE2 as well as the SARS virus. However, to their surprise, the researchers found that the spike protein of the new coronavirus actually bound far better than computer predictions, likely because of natural selection on ACE2 that enabled the virus to take advantage of a previously unidentified alternate binding site. Researchers said this provides strong evidence that that new virus was not the product of purposeful manipulation in a lab. In fact, any bioengineer trying to design a coronavirus that threatened human health probably would never have chosen this particular conformation for a spike protein.

The researchers went on to analyze genomic data related to the overall molecular structure, or backbone, of the new coronavirus. Their analysis showed that the backbone of the new coronavirus’s genome most closely resembles that of a bat coronavirus discovered after the COVID-19 pandemic began. However, the region that binds ACE2 resembles a novel virus found in pangolins, a strange-looking animal sometimes called a scaly anteater. This provides additional evidence that the coronavirus that causes COVID-19 almost certainly originated in nature. If the new coronavirus had been manufactured in a lab, scientists most likely would have used the backbones of coronaviruses already known to cause serious diseases in humans.

So, what is the natural origin of the novel coronavirus responsible for the COVID-19 pandemic? The researchers don’t yet have a precise answer. But they do offer two possible scenarios.

In the first scenario, as the new coronavirus evolved in its natural hosts, possibly bats or pangolins, its spike proteins mutated to bind to molecules similar in structure to the human ACE2 protein, thereby enabling it to infect human cells. This scenario seems to fit other recent outbreaks of coronavirus-caused disease in humans, such as SARS, which arose from cat-like civets; and Middle East respiratory syndrome (MERS), which arose from camels.

The second scenario is that the new coronavirus crossed from animals into humans before it became capable of causing human disease. Then, as a result of gradual evolutionary changes over years or perhaps decades, the virus eventually gained the ability to spread from human-to-human and cause serious, often life-threatening disease.

Either way, this study leaves little room to refute a natural origin for COVID-19. And that’s a good thing because it helps us keep focused on what really matters: observing good hygiene, practicing social distancing, and supporting the efforts of all the dedicated health-care professionals and researchers who are working so hard to address this major public health challenge.


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Posts: 22445 | Location: Occupying Little Minds Rent Free | Registered: 04 October 2012Reply With Quote
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Won’t make much difference.

Those creatures will eat anything!

Watched a program on TV sometime ago where some were drinking fresh cobra blood!

They hand the cobra from a stand, chop it’s head off and drain the blood into a container.

The man just drinks it warm.

He said it gave him youth!

And by the looks of him, it did not work at all.


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Posts: 69350 | Location: Dubai, UAE | Registered: 08 January 1998Reply With Quote
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Well, let's hope the one's who did are now dead. Cool


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Posts: 22445 | Location: Occupying Little Minds Rent Free | Registered: 04 October 2012Reply With Quote
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There is some good information here.

I was doing some contract work in CAR back in the '80s, and we had cause to visit Institut Pasteur in Bangui on a regular basis. It was when HIV was becoming a big deal, and while it was mercifully before social media as we know it, the conspiracy theorists were in full cry about it's having been lab-engineered.

Of course the doctors at the Institut could trace it back, in the primate population, to well before even gene-splicing technology had evolved.

I have no doubt that COVID-19 is a naturally-occurring zoonotic virus. As for the exact intermediate pathways that led it to man, we may never know the whole journey. Bats, pangolins, and maybe a rat or two.

I was suspicious of the motives behind the pangolin story when the "news" first broke. Perhaps it's true. But of course the rural Africans who poach pangolins, and the end-users who consume them probably don't read Forbes over breakfast, so the story would have been of very limited impact to those who matter most in the trade. Something an activist would think of. Big Grin
 
Posts: 408 | Location: Zimbabwe | Registered: 01 December 2010Reply With Quote
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Has there ever been a successful vaccine developed for any coronavirus?


~Ann





 
Posts: 19672 | Location: The LOST Nation | Registered: 27 March 2001Reply With Quote
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You realize that this started in an Iranian lab by commie Chinese scientists and the had a major fuck up takin back to China. It is all on god damn Chinese commies and the radical Islamic pigs in Iran. I hope the inbred Iranian leaders try to approach a US Navy vessel in the open seas. I am sick of the pussification of the US by the biggest wimp ever in Obama. Obama was farce and a divider.
 
Posts: 205 | Registered: 09 September 2006Reply With Quote
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Paul, we have a sandbox for political conspiracies - The Political Crater.


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Posts: 22445 | Location: Occupying Little Minds Rent Free | Registered: 04 October 2012Reply With Quote
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Please do not yell too loudly at me for being an alarmist. I had fried wild turkey last Sunday.

I ask, What is keeping some human killing virus from incubating in Whitetail Deer, wild turkey, or elk.

Hell, my family ate squirrel brains and neck bones.

My thoughts are some great power is really keeping these curses at bay for now.

What happens if CWD makes the jump?

I think the situation in China with bats and other creatures being confined closely in these markets are more evidence we should not be feed lot farming wild game species.
 
Posts: 12667 | Location: Somewhere above Tennessee and below Kentucky  | Registered: 31 July 2016Reply With Quote
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Hate to break it to you but White Tail deer carry Anthrax... along with lots of other domestic animals and wildlife.

In regards to CWD, I am afraid it and BSE have already crossed. Just visit the Political Crater for proof...


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Posts: 22445 | Location: Occupying Little Minds Rent Free | Registered: 04 October 2012Reply With Quote
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no conspiracy at all. Just hang on and watch what unfolds.
 
Posts: 205 | Registered: 09 September 2006Reply With Quote
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quote:
Originally posted by Aspen Hill Adventures:
Has there ever been a successful vaccine developed for any coronavirus?


My father created the first killed corona vaccine for cattle. I think it was in the 80s. His company was called Grand Laboratories. Lots of different companies offer it now. I vaccinate every year for it.
 
Posts: 89 | Registered: 15 August 2012Reply With Quote
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quote:
Originally posted by Opus1:
Hate to break it to you but White Tail deer carry Anthrax... along with lots of other domestic animals and wildlife.

In regards to CWD, I am afraid it and BSE have already crossed. Just visit the Political Crater for proof...


I know they are a carrier for anthrax. So, it is basically whatever power you believe in, and, maybe, lack of concentration of game into confined space preventing viruses from ever mutating to beat the immune response that is keeping the death to humanity viruses from appearing in our game meat or commercial livestock.

If that is the case, I feel our national epidemiology infrastructure is very weak. Forget, terrorist, we need to be trying to find and prevent the next virus. We may not be so lucky next time.

Viruses not being a living organism, I can get my head around. My brain is not large enough to comprehend how a virus is initials formed to start corrupting host cells.

What happens if the next virus blooms in our domestic pork industry? Said virus is not discovered until the masses have consumed and shipped all over the world.
 
Posts: 12667 | Location: Somewhere above Tennessee and below Kentucky  | Registered: 31 July 2016Reply With Quote
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Viruses are constantly mutating and eventually one mutation finds a vulnerability within a specific species and proliferates. What is interesting is viruses, specifically retroviruses, make up approximately 8% of the human genome. Without them we wouldn't exist as a species.

In regards to identifying the next, that is impossible. We are only in a defensive posture.

CV-19 is a pandemic on training wheels. When a real one hits, millions will will die.


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Posts: 22445 | Location: Occupying Little Minds Rent Free | Registered: 04 October 2012Reply With Quote
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