Any of you have any experience with this gun and this caliber for handgun hunting?

The caliber is excellent for hunting.

I have one, but haven't killed anything with it yet. The only thing I really don't love about it is the weight. mine is very accurate and reasonably easy to shoot with 405's at 1750.

mhabby, WONDERFUL GUN! I took two deer with it this season. One went 30 ft and the other 30 yds. It is also extremely accurate. I have three shots touching with the HNDY 300 gr. bullet at 50 yds. I use my LBT style boolit from a mold I made that weighs 317 grs. 1-1/4" group at 75 yds. Three out of four shots in 2" at 200 yds. Recoil is pleasant and it is a joy to shoot. I get 1535 fps with the load I am using and went over 1700 with the HNDY bullet.
It totally destroyed the insides of the deer and didn't ruin any meat. Only thing I did was to put a sling on it. carries nice now.

Lar shoots a BIG boolit! Go through an elephant!