Looking for a good accurate load in My Ruger Vaquero .44 spl. for a 300 Gr LBT WFN.

What might be accurate in their gun, might not be accurate in yours. Lyman Manuals use to list "accuracy load" and I never found them to be that good in my gun. I'd suggest you get a Lyman Manual if you don' have one and do a little experimenting.

Do a search on Brian Pearce and the .44 Special loads. He did an article in Rifle / Handloader a while back and he had a great deal of .44 Special loads including the ones your after for the heavy bullets.
dmw

There's a very good chance that bullet will shoot quite high in your handgun. I have the mold for the RCBS 300 gr. SWC that looks like the Elmer Keith bullet on steroids. In 5 different .44 Magnums it's hitting about 6 to 8" high at 25 yards. If that is the case with your gun, then a highr front sight is required. My guns have the rear sight set as low as it will go and it still 6 to 8" high.
Paul B.

Delete,

Just nosey curiosity, but why 300 grainer in the 44 SPL??

A good bear load involves a lot of H110/W296 (same powder) with magnum primers. Use 18.5 gr in my 44 magnum so you should scale back for the 44 special. This bullet has awesome penetration and stays on course much better than the classic Keith designed semi-wadcutter. Also very accurate as the same load in a Marlin 44 magnum carbine proved. Probably accurate in a revolver as well except the recoil is a bit distracting.